Non-psychotic Outcomes in Young People at Ultra-High Risk of Developing a Psychotic Disorder: A Long-Term Follow-up Study

AE Spiteri-Staines; AR Yung; A Lin; JA Hartmann; P Amminger; PD Mcgorry; A Thompson; SJ Wood; B Nelson

Journal article

Non-psychotic Outcomes in Young People at Ultra-High Risk of Developing a Psychotic Disorder: A Long-Term Follow-up Study

AE Spiteri-Staines, AR Yung, A Lin, JA Hartmann, P Amminger, PD Mcgorry, A Thompson, SJ Wood, B Nelson

Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2024

DOI: 10.1093/schbul/sbae005

Abstract

Background: The majority of individuals at ultra-high risk (UHR) for psychosis do not transition to a full threshold psychotic disorder. It is therefore important to understand their longer-term clinical and functional outcomes, particularly given the high prevalence of comorbid mental disorders in this population at baseline. Aims: This study investigated the prevalence of non-psychotic disorders in the UHR population at entry and long-term follow-up and their association with functional outcomes. Persistence of UHR status was also investigated. Study design: The sample comprised 102 UHR young people from the Personal Assessment and Crisis Evaluation (PACE) Clinic who had not transitioned t..

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University of Melbourne Researchers

Paul Amminger Author

Patrick McGorry Author

Andrew Thompson Author

Stephen Wood Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors have declared that there are no conflicts of interest in relation to the subject of this study. AS was supported by an Australian Postgraduate Award. ARY was supported by a Principal Research Fellowship (1136829). BN was supported by an NHMRC Senior Research Fellowship (1137687). AL is supported by an NHMRC Emerging Leadership Investigator Grant (2010063).